Witness appeal after fire in Newtowncunningham

first_imgWitnesses are being urged to come forward as investigations continue into a building fire in Newtowncunningham.A fire at a derelict building on Main Street last Saturday is being treated as a criminal damage incident.The building was set alight at approx 8pm on 20th July. “The fire services and Gardaí attended the scene and thankfully nobody was hurt,” said a garda spokesperson. “If anyone has any information in relation to this fire or how it started then we urge them to come forward and speak to us. The number to call is 074-9167100, Letterkenny Gardaí.”Witness appeal after fire in Newtowncunningham was last modified: July 24th, 2019 by Rachel McLaughlinShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window) Tags:Newtowncunninghamlast_img read more

Local Roundup: Redwood Empire Little League sends second team to state finals after section win

first_imgChester >> The Redwood Empire Little League 8-10 year old All-Stars defeated Chico Central in thrilling fashion on Thursday to win the Section 2 championship and earn a trip to Saturday’s state championship tournament in Yuba City.RELL opened the tournament by cruising to an 11-1 four-inning victory over Shasta Dam on Saturday followed by a 7-6 win over Chico Central two days later.On Wednesday, Chico Central bounced back, handing RELL its first loss of the tournament, 17-10.In Thursday’s …last_img

“Genomic Junk” Is Cell’s Air-Traffic Control

first_img51; Linc-RNAs (large intervening non-coding RNAs) have been promoted from junk molecules to air traffic controllers.  A mystery about these transcripts of DNA that are not translated into proteins is being explained.    Science Daily reported on work at Beth Israel Deaconess Medical Center (BIDMC) and the Broad Institute that found these RNA molecules perform a vital task.  “linc-RNAs, once dismissed as ‘genomic junk’ – have a global role in genome regulation, ferrying proteins to assist their regulation at specific regions of the genome.”  Results were published in the July 14 issue of the Proceedings of the National Academy of Sciences.“I like to think of them as genetic air traffic controllers,” explains co-senior author John Rinn, PhD, a Harvard Medical School Assistant Professor of Pathology at BIDMC and Associate Member of the Broad Institute.  “It has long been a mystery as to how widely expressed proteins shape the fate of cells.  How does the same protein know to regulate one genomic location in a brain cell and regulate a different genomic region in a liver cell?  Our study suggests that in the same way that air traffic controllers organize planes in the air, lincRNAs may be organizing key chromatin complexes in the cell.”It has been known for some time that small RNA transcripts are involved in gene regulation, but link-RNAs are often thousands of base pairs long.  The article said, “they seemed more like genomic oddities than key players” till now.  “With these latest findings, which also uncovered an additional 1,500 lincRNAs, it’s clear these RNA molecules are no mere messengers – they have demonstrated that they can and do play a leading role.”    Speaking of differences in brain cells and liver cells, another article on Science Daily smashed a paradigm: “DNA Not The Same In Every Cell Of Body: Major Genetic Differences Between Blood And Tissue Cells Revealed.”  A discovery by Montreal scientists “calls into question one of the most basic assumptions of human genetics: that when it comes to DNA, every cell in the body is essentially identical to every other cell.”  It appears that biologists and geneticists are finding new complexities in the way genes are distributed and regulated in body cells.  The discoveries may lead to better understanding of the factors that make cells in various tissues look and behave differently.Neither of these articles needed evolutionary theory.  When the trend in scientific discovery is to uncover more and more complexity, regulation, and function such that air traffic control is the analogy that comes to mind, intelligent design “leaps up as the most likely explanation,” as Jonathan Wells put it.  Pilot Charlie, preferring unguided processes, appears headed for a nose dive.(Visited 10 times, 1 visits today)FacebookTwitterPinterestSave分享0last_img read more

DNA Translation Has Codes Upon Codes

first_imgThe DNA code is protected by another code, and is read with a machine that reads a third code.  This is an emerging picture from ongoing research into DNA transcription, as reported in Science.1    In the 1950s, scientists were astonished to find a code at the genetic basis of life.  DNA’s four-letter alphabet, arranged into triplet codons, providing 64 combinations that could code for the 20 amino acids and “punctuation” in various ways, seemed simple and elegant (see description in our online book).  Now it seems, remarkable as this mechanism is, it is way too simple.  Other factors must control when and how particular genes are to be transcribed.  Biochemists have also been cataloguing a huge number of post-transcriptional and post-translational modifications that take place, from the moment messenger-RNA is formed to after the protein chain is assembled.  What controls the regulators?    Additional codes involved in regulating gene expression have been coming to light.  One was the histone code attached to DNA (11/13/2007) which may be as complex and as important as the DNA code itself (04/12/2003).  Now, Science published two papers on another code attached directly to the transcriber, RNA Polymerase II.  This “CTD code” is composed of tandem repeats of seven amino acids forming a tail called the carboxy-terminal domain (CTD).  New work expands the previously-known number of phosphorylation states from four to eight.  Since each of these amino acids can be modified by phosphorylation, patterns emerge that resemble a hexadecimal system.  Because the tandem repeats vary from 17 to 52 sets on a CTD, if each phosphorylation pattern had a functional meaning, there are potentially 852 different CTD patterns – over 900 trillion trillion trillion trillion.    Such a number is probably degenerate – i.e., vastly greater than the number of states that are actually needed for functional meaning.  Still, the potential is there for a huge array of states that can direct the behavior of RNA Polymerase II.  It also might help explain why the number of genes in the human genome was surprisingly low; perhaps the CTD code provides a way to get more transcripts out of a gene – resulting in many proteins from one gene.  Experiments have shown that some distinct phosphorylation patterns do indeed change the expression of the gene.  Jeffry Corden [Johns Hopkins U] wrote in the review article on the two papers,The biological role of CTD phosphorylation remains to be fully elucidated, but the emerging picture is that the pattern of CTD phosphorylation changes during RNA synthesis, allowing dynamic modification of the DNA template and processing of the nascent RNA transcript.  The studies by Chapman et al.2 and by Egloff et al.3 provide both the tools to fully document CTD phosphorylation patterns and the best evidence to date that these patterns constitute a code that intersects, at the most fundamental level, with the regulation of different classes of eukaryotic genes.It appears that both DNA and its transcriber have codes, completely independent from the DNA code, affixed to them.  Are they passwords forming an authentication scheme?  Are they messages telling the machinery what to do?  If so, what sends the messages, and what recognizes them?  How is the password validated?  More work into this fascinating area will surely be needed.  For now, Corden said, “Together, the papers show that CTD phosphorylation is more complicated than previously thought and link, for the first time, expression of specific genes with a distinct CTD phosphorylation pattern.”1.  Jeffry L. Corden, “Seven Ups the Code,” Science, 14 December 2007: Vol. 318. no. 5857, pp. 1735-1736, DOI: 10.1126/science.1152624.2.  Chapman et al, “Transcribing RNA Polymerase II Is Phosphorylated at CTD Residue Serine-7,” Science, 14 December 2007: Vol. 318. no. 5857, pp. 1780-1782, DOI: 10.1126/science.1145977.3.  Egloff et al, “Serine-7 of the RNA Polymerase II CTD Is Specifically Required for snRNA Gene Expression,” Science, 14 December 2007: Vol. 318. no. 5857, pp. 1777-1779, DOI: 10.1126/science.1145989.The situation just keeps getting worse for the evolutionists.  None of the three papers even mentioned evolution.  Who would dare?    Apparently, Science Daily dared.  Summarizing these papers, it said, “It would appear that, over the last 500 million years, other ways to produce highly complex organisms have evolved.  Evolution has simply found more efficient ways to use the genes already there.”  You may now utter a long, sarcastic groan.(Visited 11 times, 1 visits today)FacebookTwitterPinterestSave分享0last_img read more

Ohio Cattlemen’s Association launches Cattlemen’s Academy

first_imgShare Facebook Twitter Google + LinkedIn Pinterest The Ohio Cattlemen’s Association (OCA) will launch a new producer education program in the fall of 2019, the OCA Cattlemen’s Academy. OCA recognizes the importance of serving individual members across the state, and the goal of the Cattlemen’s Academy is to offer informative, hands-on learning experiences as part of a current OCA membership. Each year, the program will focus on a different aspect of the cattle industry with a new meeting series that is important to producers in the state of Ohio.As its first series, the Cattlemen’s Academy will host calving clinics at multiple locations throughout Ohio in conjunction with the Department of Animal Sciences at The Ohio State University. Producers will learn how to determine calf presentations and more about calving assistance techniques and calving facilities design. They will also be instructed on nutritional management of the prepartum cow and bull selection for calving ease. Various experts from Ohio State and the cattle industry will be on-hand to instruct attendees and answer questions throughout the clinics.The Cattlemen’s Academy calving clinics are free for OCA members to attend. Those who are not current OCA members may still attend but must pay $75 per family upon registration. This cost includes clinic attendance and an OCA membership. A meal is included for each participant at each of the clinics, sponsored by Merck Animal Health. Producers should make plans to attend, or risk missing out on the chance to take part in this unique learning opportunity for their operations. Each clinic is limited to the first 100 registrants, so those interested should register early.The first calving clinic will take place at 6:00 p.m. on Monday, September 30, 2019 at the Ohio Agricultural Research and Development Center (OARDC) Eastern Agricultural Research Station in Noble County, Ohio: 16870 TR 126 Caldwell, Ohio 43724. Additional calving clinics will be announced throughout the remainder of 2019.For more information or to register for a clinic, visit ohiocattle.org, call the OCA office at 614-873-6736 or contact OCA Director of Education, Kagney Collins at [email protected]last_img read more

LeBron James scores 36 as Lakers end 5-game skid by beating Bulls

first_imgTrump campaign, GOP groups attack Google’s new ad policy P2.5 B shabu seized in Makati sting, Chinese national nabbed It was James’ highest-scoring game since Dec. 18.Kyle Kuzma added 21 points after missing two games with an ankle injury. Kentavious Caldwell-Pope scored 24 points off the bench for the Lakers, who outscored the Bulls 43-24 in the third quarter.Lopez had 20 points and seven rebounds, and Otto Porter Jr. finished with 19 for the Bulls.With Lonzo Ball and Brandon Ingram ruled out for the season, James put on a show at United Center like he did so many times as a member of the Cavaliers and Heat.The Bulls outscored the Lakers 11-1 after he checked out in the first quarter to lead 34-16 at the end of the period.ADVERTISEMENT SEA Games hosting troubles anger Duterte Bulls: Boylen expects Zach LaVine, who missed his second straight game, to return this season. There is no timetable on LaVine’s return. He is out with a right patellar strain. “I’m optimistic. I’m not eyeing a return date, but I’m optimistic,” Boylen said. “Our training/medical is optimistic so he wants to play. He was in a nice groove, nice rhythm. I think he wants to get back at it. He’s done his treatment, he’s been early he’s stayed late to do his stuff, so he’s working at it.” . Wayne Selden was hit with consecutive technicals late in the third quarter to get ejected.UP NEXTLakers: Visit Toronto on Thursday.Bulls: Visit the Los Angeles Clippers on Friday.Sports Related Videospowered by AdSparcRead Next Don’t miss out on the latest news and information. PH underwater hockey team aims to make waves in SEA Games PLAY LIST 02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games02:11Trump awards medals to Jon Voight, Alison Krauss 1 dead, 3 injured in Quezon road crash Lacson backs proposal to elect president and vice president in tandem Then something finally start to click for the Lakers.“We started to have fun,” Kuzma said. “Everybody had a joy for the game, happy for each other. Everybody was moving the ball, passing it. It felt like everybody got shots tonight.”The Bulls led 60-55 at the half. Ryan Arcidiacono and Lopez led Chicago with 12 apiece. James finished with 16 points and seven rebounds in the half and Caldwell-Pope added 11 points.James continued the momentum in the third quarter. He scored the first six points for Los Angeles, including a breakaway reverse dunk from Kuzma. The Lakers took a 66-64 lead when James found Kuzma for a layup with 8:49 in the third quarter. Kuzma, who scored 12 points in the period, made a 3 to ignite a 16-0 run late in the quarter. Rajon Rondo buried a 3 to give the Lakers a 98-84 lead going to the fourth.“We got defensive stops and we made some shots. We were very in-tune with what we needed to do defensively and our second-unit guys came in with energy and effort,” James said.Lauri Markkanen struggled again with his shot. He was 4 of 17 for 11 points.“To say something is wrong with him I think would be premature and not correct. To say, we need him to play better for us to have a chance to win is the way to say it,” Bulls coach Jim Boylen said. “Whether it is rebounding the ball and bringing it, which he needs to do more of. He was playing well, he was doing more of that. And he needs to, obviously, make open shots.”TIP-INSLakers: Coach Luke Walton has not made a decision on if he will rest James in one of the back-to-back games on Thursday and Friday in Toronto and Detroit. Before the game, Walton was asked what would’ve been his reaction if he was told they would have the same record (30-36) as they did after 66 games last season.“I would’ve assumed that we got hit with a lot of injuries. If you told me we were healthy, I would’ve told you there is something wrong. But it is where we are at right now as a group and it is our job to continue to come out and give everything we can to get better to win what games we do have left,” Walton said. Los Angeles Lakers forward LeBron James (23) dunks in front of Chicago Bulls guard Antonio Blakeney (9) during the second half of an NBA basketball game Tuesday, March 12, 2019, in Chicago. (AP Photo/Nuccio DiNuzzo)CHICAGO — Less than a week after passing Michael Jordan for fourth on the NBA’s career scoring list, LeBron James delivered a memorable night at the arena Jordan first made famous.James had 36 points and 10 rebounds, and the Los Angeles Lakers overcame a 20-point deficit to beat the Chicago Bulls 123-107 on Tuesday night and end a five-game losing streak.ADVERTISEMENT James played 33 minutes and showed no signs of letting up with the Lakers barely hanging on in the playoff race. He took over after the Lakers’ 14-point lead was cut to four with 8:38 left, making a jumper and then on the next possession going through the lane for a thunderous dunk.James didn’t stop there, hitting a 3-pointer over 7-footer Robin Lopez and capping it off when Josh Hart passed the ball off the backboard to James, who finished with a reverse dunk to put the Lakers up 115-101 with 5 minutes remaining.FEATURED STORIESSPORTSPrivate companies step in to help SEA Games hostingSPORTSUrgent reply from Philippine ‍football chiefSPORTSPalace wants Cayetano’s PHISGOC Foundation probed over corruption chargesJames was asked if he had any special thoughts returning to the United Center.“Not really, but I definitely recognize the greatness Mike had in this city,” James said. “Pretty much every time I play here I look up at the rafters, look up at the jersey retired and then when the starting lineups come up, when I was a kid watching that starting lineup watching the Bulls run through the city and Jordan’s name and number getting called, I always have that feeling.” Ben Simmons, Sixers survive scare from short-handed Cavaliers Urgent reply from Philippine ‍football chief Private companies step in to help SEA Games hosting LATEST STORIES MOST READ Hong Kong tunnel reopens, campus siege nears end View commentslast_img read more