Salutation/ Introduction:Thank you Dr. Contis for your kind introduction. The people of Liberia are grateful for the work your organization has conducted to strengthen Liberia’s health care system and the support of the American people as Liberia struggles to recover from the devastating impact of Ebola.Thank you Dr. Betancourt, The Universal Peace Federation and The Washington Times for the invitation and the opportunity to inform members of the global community about the health and development challenges that Liberia and the neighboring countries of Guinea and Sierra Leone are struggling to overcome.Congressman Williams, on behalf of President Ellen Johnson Sirleaf, the government and people of Liberia, we thank the United States and your generous support through the deployment of U.S. military personnel from your Congressional district to construct 17 (100-bed containment units), as well as the other work US military personnel are doing to strengthen the health infrastructure in Liberia. We are also profoundly indebted to the private sector, the public health community, and humanitarian organizations for their assistance. Distinguished invited guests,Liberia has come a long way; a small country on the West Coast of Africa, just about the size of the State of Ohio. Founded by freed American slaves in 1822, Liberia continues to enjoy a historic relations with the United States. In fact, the United States remains the most important development partner of Liberia.Since March 2014, nearly every hour the media has reported increasingly grim details about the fierce threat and devastating impact of Ebola. The World Health Organization has estimated that Ebola will affect 1.4 million lives, if proper corrective measures were not instituted. While we do not doubt the WHO estimate, we do know that the impact of the disease is not just measured in human lives. The Ebola outbreak has a variety of consequences – and unfortunately – all of them are grim – and some of them will even be felt by those participating in this forum.One of my most important concerns as Liberia’s diplomatic representative to the United States is that we must control the panic factor to prevent Liberia from becoming forever dependent on the donor community and to encourage the private sector to not lose faith in our ability to be investment worthy.Prior to the outbreak of Ebola, there were only 50 medical doctors in Liberia, a few dentists and one psychiatrist for the entire population of 4.1 million people. A 14-year-civil war destroyed the country and devastated its infrastructure and claimed the lives of more than 250,000 people, displaced about one million of its citizens. The country experienced a huge brain drain. Therefore, when the deadly Ebola virus hit Liberia, our system was overwhelmed and could not contain the virus and stop its spread.The Ebola virus disease has claimed the lives of 2,800 people, including 131 healthcare workers, leaving about 3,000 orphans behind and about 5,000 currently infected. We applaud the support of the United States and the international community, and should like to report of a recent decline in the outbreak of new cases. We, however, like to reiterate that much more is needed to be done to eradicate the virus.Therefore, a compelling case can be made for an accelerated international response to eliminate Ebola by working with us to rebuild our health infrastructure, provide critical supplies and health services (including the further development of a vaccine), and as important – by investing in systems and sectors to ensure economic stability and security for Liberia and the region.Friends of Liberia and our dear partners, since the end of the civil war, Liberia has been making steady progress towards economic resurgence. Liberia was beginning to be regarded as a post-conflict success story in Africa, consolidating its peace and democracy. Political stability created the enabling environment for foreign investment in iron ore, maritime, rubber industry, tourism, and construction of ocean front resorts, as well as, infrastructure (particularly telecommunications and energy).Unfortunately, Ebola – and its wide ranging multi-sector impact, has plunged Liberia into limbo, both in terms of economic development and geo-political insecurity. In 2013, Liberia was among the top 10 countries with the highest GDP growth rate. Its GDP was expected to grow by 5.9% in 2014, but the expected gain has been reversed to 2.5%.In addition to the enormous and tragic loss of human life, the Ebola epidemic is having devastating effects on the Liberian economy in a variety of essential sectors by halting trade, hurting agriculture and scaring investors. For example:a) Agriculture accounts for 39% of Liberia’s GDP. Disruptions from the outbreak will result in diminishing yields of Liberia’s staple food, such as rice and cassava. Prices of these commodities are already increasing exponentially. Such shocks will push inflation to 13% from 7% prior to the Ebola outbreak.b) Mining activity, which constitutes 14% of the economy is decreasing. China Union and ArcelorMittal are scaling down iron ore mining. c) Fiscal revenues will decline as limited economic activity reduces revenues from taxes, tariffs and custom duties. At the same time, to resolve the crisis and meet health and security needs of the people, government expenditure will increase, with a short-term fiscal impact of $93 million or 4.7% of GDP.Dear friends of Liberia,I have come here therefore, to gain the support that is essential to redevelop Liberia and restore its future. Liberians are a resilient people – with help they can make it happen. While our immediate focus is on the eradication of the Ebola virus disease, we are equally concerned about post-Ebola recovery programs.These are the reasons that international aid must be sustained and new investment made for the growth and survival of Liberia:Ebola has made Liberia and the region vulnerable to bio-terrorism. We have witnessed how bio-terrorism has undermined the security in other parts of the world.The Liberian family, ordinarily strong, responsible, and vibrant, has broken down. Wage earners have lost their lives. Children with no extended family are orphaned. International human traffickers are preying on those women and children without the capacity to maintain themselves or lack of access to the few services currently available to assist them with this life transition.The infrastructure, particularly electricity, is not reliable and operates only a few hours each day, at a rate of 54 cents per kilo watt hour; perhaps, the highest in the world. Investment in solar energy to reduce the strain on the country’s power grid is essential in order to adequately support the containment units being built and restore Liberia’s business community. It is critical that Liberia and its neighboring countries develop the capacity to prevent future epidemics. Failure to implement a comprehensive strategy to provide effective prevention mechanisms and life saving care not only helps to reduce deaths but ensures the confidence of the population that their government values human life and their family and the prosperity of the country.With continued help from the United States, people like you, and the donor community, frustration and civil disobedience and outside agitation will be stemmed. Finally, ladies and gentlemen, friends of Liberia, the take away message today is that:We are not asking you to feel sorry for Liberia or to view it as a “basket case”. We are asking you to believe in Liberia and value its history as an important U.S. allyWe are asking you to realize that unless the Ebola virus gets under control, the country is vulnerable for violence and discontent – and if that in fact occurs the country is destined for generations of poverty and will be ripe for crisis.If just every third person in this room is willing to contribute even one box of medical gloves, and companies take a risk with us to invest in Liberia’s private sector, the next time I address you I will be presenting a positive, encouraging report on Liberia’s resurgence. Thank you for being concerned enough about this crisis to attend today. Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window)
Journal information: Nature Citation: A new way to create macrolides—from scratch—may help in battle against bacterial resistance (2016, May 19) retrieved 18 August 2019 from https://phys.org/news/2016-05-macrolidesfrom-scratchmay-bacterial-resistance.html For many years, the go-to drugs of choice for treating a variety of bacterial infections has been macrolides, which are all drugs that have been created by altering a natural form of erythromycin—but in recent years, bacteria have become resistant to many of the drugs that have been developed. New ones have been slow in coming, due to the difficulty in finding new ways to alter the original bacteria which means R&D costs have been rising. This development has led to near-panic in the health community as it appears that if something does not change soon, the arsenal of weapons used to fight many infections will be vastly depleted. In this new effort, the researchers report that they have found a new way to create new variations of macrolides that does not require using native erythromycin as a source—instead, they create them from scratch. This development means that many more variants can be created at far lower cost, helping to keep ahead of bacterial resistance.To create new macrolides, the team reports, they used a method that allows for modular building, which they liken to the way cell phones are made—they start by building small-chemical blocks and then “weld” them together using a process that requires very few steps. They report also that the technique can be applied on a multigram scale, which means enough can be created at a time for use in experiments geared towards testing the results in killing bacteria.To date, the team has produced 300 macrolides using their technique, which include some that have had already been created using the original method. They report that some have already been tested to see how well they fight bacteria and have met with some initial success. They acknowledge that a lot more work needs to be done to find out if drugs produced using the method are truly effective in fighting bacterial infections and if so, if they will prove to be safe for use in humans. Erythromycin. The macrolide ring is the lactone (cyclic ester) at upper-left. Credit: Public Domain More information: Ian B. Seiple et al. A platform for the discovery of new macrolide antibiotics, Nature (2016). DOI: 10.1038/nature17967AbstractThe chemical modification of structurally complex fermentation products, a process known as semisynthesis, has been an important tool in the discovery and manufacture of antibiotics for the treatment of various infectious diseases. However, many of the therapeutics obtained in this way are no longer effective, because bacterial resistance to these compounds has developed. Here we present a practical, fully synthetic route to macrolide antibiotics by the convergent assembly of simple chemical building blocks, enabling the synthesis of diverse structures not accessible by traditional semisynthetic approaches. More than 300 new macrolide antibiotic candidates, as well as the clinical candidate solithromycin, have been synthesized using our convergent approach. Evaluation of these compounds against a panel of pathogenic bacteria revealed that the majority of these structures had antibiotic activity, some efficacious against strains resistant to macrolides in current use. The chemistry we describe here provides a platform for the discovery of new macrolide antibiotics and may also serve as the basis for their manufacture. © 2016 Phys.org Explore further Linking antibiotic to antibody found able to kill MRSA hiding in mice cells (Phys.org)—A team of researchers at Harvard University has found a way to create new macrolides—a class of drugs used to fight bacterial infections. In their paper published in the journal Nature, the team describes their approach and why they believe it might be useful in keeping ahead of bacterial resistance until something more revolutionary comes along. Ming Yan and Phil Baran with The Scripps Research Institute, offer a News & Views article outlining the work done by the team and why they believe the new technique may help medical researchers keep up with bacterial evolution. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.