Dr. Subhash Basu, professor emeritus of chemistry and biochemistry, will embark on a speaking tour of India on Tuesday to discuss his current research on potential new anti-cancer drugs. Basu will make his second appearance at the International Cancer Research Symposium on Dec. 19 in Calcutta when he gives a lecture titled “Probable New Therapeutic Drugs for Breast and Colon Cancers.” “The invitation to this symposium is very prestigious. Sixty people from all over the world are going to Calcutta,” he said. “I will tell them what our plan is for the delivery of these new anti-cancer drugs.” Basu’s lecture tour will also include an appearance at the Indian Science Congress on Jan. 4, where he will discuss the apoptotic, or cell-killing, effects of the drugs he is working with his collaborators to develop. “Our work is important, and we get an invitation every year to speak at these sorts of things,” he said. Basu said he and his research team have discovered five to six different new anti-cancer compounds that would be useful for treating colon and breast cancer patients. “These chemicals are quite toxic to biological cells and they kill cancer cells by enhancing apoptosis, or programmed cell death, in a very micro amount,” he said. Now that these cancer-killing compounds have been discovered, Basu said the main goal of his work is to determine ways to deliver the drugs into patients at the location of the cancer without harming the healthy cells around the cancerous ones. “Cancer cells normally die of necrosis – they make holes in themselves,” he said. “When apoptosis happens, the cell gets bigger and its DNA starts degrading until the cell cannot function.” Basu said about 50,000 women die of breast cancer in the United States each year, so his research could impact thousands of lives in the future. “Chemotherapy could be improved by our procedure by giving patients micro doses of drugs so they don’t kill the normal cells,” he said. “Thus, the success of these apoptotic chemicals as anti-cancer drugs depends on their proper delivery to the cancer sites.” To facilitate and fund his research in this area, Basu founded the Cancer Drug Delivery Research Foundation (CDDRF) in 2010, of which he serves as president. The foundation received its first major source of support when the University transferred all of Basu’s recoupment to CDDRF in May, he said. “All this recoupment was brought in by me from federal grants and other sources during my time at the University,” Basu said. “This foundation is tax-exempt and will help only for my research, so any patent money we get can go into the research as well.” Basu said his status as a permanently appointed emeritus professor gave him the freedom to move his lab from campus to a currently undetermined site near campus. “The University said I would have to give half of whatever I bring in to Notre Dame if I continue to work in a lab here,” he said. “It becomes cheaper for me to run my lab outside because I can use 100 percent of my money for research.” Since joining the faculty at Notre Dame in 1970, Basu has received major grants from the National Institutes of Health and the National Cancer Institute.
By Sharon OmahenUniversity of GeorgiaCooking and sharing meals with loved ones is a traditional part of the holiday season. But don’t forget to take care of the leftovers, or you could invite foodborne illnesses to your holiday party, says a University of Georgia food safety expert.”It’s great to spend time with family members after a holiday dinner. Just take the time to put away food dishes first,” said Michael Doyle, director of the UGA Center for Food Safety in Griffin, Ga.Refrigerate or freeze holiday meals within two hours of serving them, he said. Refrigerators should be set at 41 degrees Fahrenheit or below. Freezers should be at 0 degrees Fahrenheit or below.”Temperatures are critical when it comes to keeping food safely stored and cooking food,” Doyle said. “Many home refrigerators are way out of the safe zone of 41 degrees Fahrenheit. A refrigerator set at 50 degrees Fahrenheit is what we microbiologists call an incubator. That’s where we grow bacteria for research.”Whether you’re making leftover ham or turkey dishes, be sure to reheat leftovers to at least 165 degrees Fahrenheit, Doyle said.After four days, though, leftovers should be eaten, frozen or thrown away, he said.“Americans like to share food along with their good times and celebrations. But without using proper handling rules, you could share foodborne illness with your family and friends,” said Elizabeth Andress, a food safety specialist with the UGA College of Family and Consumer Sciences.She offers these tips for proper food handling:* Wash your hands before and during food preparation.* Defrost frozen meats, poultry and fish inside your refrigerator or below 40 degrees Fahrenheit and thoroughly cook food immediately after defrosting in a microwave.* Clean and sanitize food preparation surfaces after exposure to raw meats, poultry, fish or eggs.* Cook ground beef and other meats, poultry and eggs thoroughly.* To store food, divide into smaller quantities that will cool quickly.* Transport food in insulated carriers designed for hot or cold foods. Keep hot foods above 140 degrees Fahrenheit.
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Marco Gonzales, SP, Mariners. Gonzales did not shut down the Athletics offense in the opener, but he did pick up a quality start and a win by holding Oakland to three runs over six innings pitched. He only needed 69 pitches to get through the six innings and pick up four strikeouts. He is a solid pitcher, and this felt like the type of game we can expect more of from him, so his stock shouldn’t change much.Hunter Strickland, RP, Mariners. Strickland shut down the A’s offense in order in both games, picking up three Ks and two saves in the process. Strickland isn’t going to be a top closer this year by any means, but after these two outings I would be shocked if he continues to go at the 279 ADP mark that he had over the last week. Fantasy owners will always chase saves, and Strickland’s stock is going to rise with this strong showing.*ADPs are based on NFBC drafts. The MLB regular season is here! Well, sort of. However, fantasy baseball drafts are still taking place and perceived values will continue to change right up until opening day in the State. It’s important to pay attention to ADP trends and why rankings are fluctuating, be it because of injuries (Luis Severino) or particularly good/bad play.If your league already drafted, this piece can be used for trading and/or waiver wire purposes. Keeping up with the trends is crucial to fantasy success. So, whose values are changing and why? GET IT NOW: Fantasy Alarm Draft GuideFantasy Baseball Stock Watch: ADP risersMichael Conforto, OF, Mets. Conforto bashed his fourth spring training home run on Monday and the fantasy world is taking notice. Over the past week his ADP is inside the top 100 at 98, which is up five spots from his 103 mark in the previous week. To go along with the four home runs, Conforto has 10 RBIs, a stolen base, and is hitting at a .265 clip across 49 spring at-bats. He is coming off career-high totals in home runs (28), RBIs (82), runs scored (78), and stolen bases (3). All of which came despite a very sluggish April in which he hit .222 with just one home run as he was working his way back from his shoulder injury. If we just look at his post-break numbers, his stat line becomes very impressive, as he was able to hit .273 with 17 home runs and 52 RBIs across 256 at-bats. Conforto was my choice for “must-own” player in the Fantasy Alarm Bold Predictions, and even at his current increased price he is someone you will want to draft.Jack Flaherty, SP, Cardinals. Flaherty’s ADP has been on a pretty steady rise throughout the draft season, and it continued this week as it moved up another six spots to 53. Flaherty had a stellar rookie season last year, finishing with a 3.34 ERA and 182 strikeouts across 151 innings pitched. He was only 22 last year, but he already had the look of an ace in the making. His strong spring – 2.77 ERA and 19 strikeouts across 13 innings pitched – has done nothing but vault him further up draft boards as the season draws near. The Cardinals recently announced that he will pitch the second game of the season, and that also means that he will likely take the ball for their home opener on April 4. The Cardinals made improvements to their offense and to their bullpen this offseason, which should help the starters win more games and Flaherty could cross the 200-K mark, all of which make him a high upside grab in fantasy.Jorge Soler, OF, Royals. Soler had a massive jump in ADP this week up to 312, 47 spots higher that his 359 mark in the week prior. When looking at players this late in the draft it doesn’t take much for big ADP swings and Soler’s torrid spring – .310 batting average, four home runs, 14 RBIs, 10 runs – has seemingly done just that. Soler has long been thought of as a guy with big-time power potential, but he has never been able to put it together. Through five big league seasons his career-high home run total is only 12, but he has also failed to ever surpass 366 at-bats. The potential is still there, though, and if he can stay healthy he could finally be in for a bit of a breakout campaign. He is going to hit fourth or fifth in the Royals lineup and a 20-plus HR season is a possibility.2019 Fantasy Baseball Rankings:Catcher | First | Second | Third | Short | Outfield | Starter | Reliever | Top 300Fantasy Baseball Stock Watch: ADP fallersWilmer Flores, 1B/2B/3B, Diamondbacks. Flores (potential) owners are not fans of the Diamondbacks recent signing of Adam Jones, and it shows in his ADP dropping to 443, down 57 picks from his 386 mark in the week prior. Flores was a popular late-round pick, as he was slated to be the D-backs everyday second baseman and flashed some pop with the Mets in a limited role, but the recent addition of Jones puts a big damper on those aspirations. With Jones coming in, Ketel Marte will be spending less time in CF and more time at second base. Flores should still see a healthy amount of at-bats, but he is no longer a trendy fantasy pick.Luis Severino, SP, Yankees. Recent news came out that Sevy is out until at least May, and it has sent his draft stock into an even further downward spiral. This week he was being draft on average at pick 91, down 25 spots from his 66 mark in the week prior. Shoulder issues can be tricky, and there is good reason to worry about his injury in regards to your fantasy roster. Of course, leagues with DL spots make it a lot easier to sit on him and get strong production once he comes back, but in leagues without DL slots he is a tough sell right now. He is electric and the Yankees will win a lot of games, but that doesn’t do you a whole lot of good if he isn’t taking the mound. His ADP will likely continue to slide as the season approaches.Sean Newcomb, SP, Braves. Newcomb was a popular late-round pick in last year’s drafts after he posted a solid 9.7 K/9 across 100 innings as a rookie in 2017. He made good on that pick in the first half of last season as he was 8-5 with a 3.51 ERA and 97 strikeouts at the break. However, a weak second half in which he posted a 4.58 ERA and 1.42 WHIP had his stock a bit lower heading into this year. Fast forward to spring training and Newcomb has been absolutely horrendous, sinking his ADP. This week his ADP was down to 264, a 32-pick drop from his 232 mark in the week prior. Newcomb has a history of control issues, so his 10 walks across 12 innings pitched in spring training are very uninspiring. He also only has seven strikeouts and has given up seven earned runs. Newcomb still has upside, but his stock is fairly taking a big hit.GET IT NOW: Fantasy Alarm Draft GuideFantasy Baseball Stock Watch: Players to watchWith our first two regular season games in the books, we have some action to discuss! No, two gamse should not change anyone’s stock/value, but if you have played fantasy long enough, you know it is going to anyways!Ramón Laureano, OF, A’s. Laureano had an abysmal first game of the season, finishing 0-for-5 with three strikeouts. Strikeouts are a problem here, as he struck out 50 times across 156 at-bats as a rookie last season and already had 11 across 33 spring training at-bats before the opener. He was dropped to eighth in the order in Game 2, but he went 2-for-5 despite two more Ks.Tim Beckham, SS/3B, Mariners. Beckham had a really nice 2017, but he was a complete disappointment lastl year. However, it’s 2019 and Beckham is arguably the best player on the planet (kidding, of course). He had a monster first game as he finished 3-for-3 with a home run, three runs, two RBIs, and a walk. He turned in another two hits and a run in the second. I can bet you that you start seeing people pick this guy at the end of their drafts.Domingo Santana, OF, Mariners. Santana had a spot in this piece last week as a stock riser and went out and hit an opposite-field grand slam in his first game of the season. He then went 1-for-5 with an RBI and stolen base in the second game. You can expect his stock to continue to rise and it may get out of hand. I would not be surprised to see him start getting picked around 150 in drafts this week — and that might just be what it takes to get him if you want him.