Dr. Subhash Basu, professor emeritus of chemistry and biochemistry, will embark on a speaking tour of India on Tuesday to discuss his current research on potential new anti-cancer drugs. Basu will make his second appearance at the International Cancer Research Symposium on Dec. 19 in Calcutta when he gives a lecture titled “Probable New Therapeutic Drugs for Breast and Colon Cancers.” “The invitation to this symposium is very prestigious. Sixty people from all over the world are going to Calcutta,” he said. “I will tell them what our plan is for the delivery of these new anti-cancer drugs.” Basu’s lecture tour will also include an appearance at the Indian Science Congress on Jan. 4, where he will discuss the apoptotic, or cell-killing, effects of the drugs he is working with his collaborators to develop. “Our work is important, and we get an invitation every year to speak at these sorts of things,” he said. Basu said he and his research team have discovered five to six different new anti-cancer compounds that would be useful for treating colon and breast cancer patients. “These chemicals are quite toxic to biological cells and they kill cancer cells by enhancing apoptosis, or programmed cell death, in a very micro amount,” he said. Now that these cancer-killing compounds have been discovered, Basu said the main goal of his work is to determine ways to deliver the drugs into patients at the location of the cancer without harming the healthy cells around the cancerous ones. “Cancer cells normally die of necrosis – they make holes in themselves,” he said. “When apoptosis happens, the cell gets bigger and its DNA starts degrading until the cell cannot function.” Basu said about 50,000 women die of breast cancer in the United States each year, so his research could impact thousands of lives in the future. “Chemotherapy could be improved by our procedure by giving patients micro doses of drugs so they don’t kill the normal cells,” he said. “Thus, the success of these apoptotic chemicals as anti-cancer drugs depends on their proper delivery to the cancer sites.” To facilitate and fund his research in this area, Basu founded the Cancer Drug Delivery Research Foundation (CDDRF) in 2010, of which he serves as president. The foundation received its first major source of support when the University transferred all of Basu’s recoupment to CDDRF in May, he said. “All this recoupment was brought in by me from federal grants and other sources during my time at the University,” Basu said. “This foundation is tax-exempt and will help only for my research, so any patent money we get can go into the research as well.” Basu said his status as a permanently appointed emeritus professor gave him the freedom to move his lab from campus to a currently undetermined site near campus. “The University said I would have to give half of whatever I bring in to Notre Dame if I continue to work in a lab here,” he said. “It becomes cheaper for me to run my lab outside because I can use 100 percent of my money for research.” Since joining the faculty at Notre Dame in 1970, Basu has received major grants from the National Institutes of Health and the National Cancer Institute.
..Dale Steyn suffers another injury blowBy Nick SaidCAPE TOWN (Reuters) – South Africa built a sizeable lead after reaching 65 for two against India at the close on day two of the first Test at Newlands on Saturday but must finish the match without pace bowler Dale Steyn who suffered another injury setback.Hashim Amla (four not out) and nightwatchman Kagiso Rabada (two not out) will seek to extend the home side’s advantage of 142 runs with eight second-innings wickets remaining after they bowled India out for 209 on a lively wicket offering plenty of assistance for the bowlers. Steyn, who only returned to the side for this match after 14 months out with a shoulder injury, left the field having bowled 17.3 overs and went for scans on an injured heal. South African team manager Mohammed Moosajee confirmed Steyn’s worst fears as he now faces four-six weeks on the sidelines with tissue damage after landing awkwardly in his delivery stride.“Understandably he is disappointed, but he will try his best to recover as quickly as possible. You could see how much he was enjoying himself out there,” Moosajee told reporters. Being a bowler light will probably make South Africa rethink what is a good target to set India to win the game. Aiden Markram (34) was the first wicket to fall having looked fluent until he top-edged a rising delivery from Hardik Pandya (2-17) to Bhuvneshwar Kumar at a deep point.Dean Elgar (25) was scratchy throughout his stay at the crease and became Pandya’s second victim when he edged to wicketkeeper Wriddhiman Saha. Pandya earlier ensured India stayed in the contest with a brilliant 93 from 95 balls, including 14 fours and a six as he alone provided resistance to the venomous home attack. LUCKY PANDYA The all-rounder had watched as his side slipped to 92 for seven but instead of playing for survival, Pandya took the attack to the South African seamers. He had his fair share of luck, dropped at gully by Elgar off Steyn on 15 and offering a stumping chance to wicketkeeper Quinton de Kock that was spurned.Having been roughed up by a barrage of short-pitched bowling from the excellent Rabada (3-34), the latter finally ended Pandya’s stay as he induced an edge to De Kock. “He is someone who is really promising, and is bowling and batting well, and that makes a difference to the team because when you have a good all-rounder it improves the balance,” India batsman Cheteshwar Pujara said.“He kept us in the game and got us two wickets at the end of the day as well.” The rest of the batsmen found it difficult to score against the fast and accurate home bowling with Pujara’s patient 26 from 91 balls the next highest score. South Africa host India in three tests this month with the next two in Pretoria and Johannesburg.SOUTH AFRICA 1st innings (286)India 1st innings (overnight 28-3)Vijay c Elgar b Philander 1Dhawan c & b Steyn 16Pujara c du Plessis b Philander 26Kohli (c) c de Kock b Morkel 5Sharma lbw Rabada 11Ashwin c de Kock b Philander 12Pandya c de Kock b Rabada 93Saha lbw Steyn 0Kumar c de Kock b Morkel 25Shami not out 4Bumrah c Elgar b Rabada 2Extras: (lb-,13lb) 14Total: (all out 73.4 overs) 209Fall of wickets: 1-16, 2-18, 3-27, 4-57, 5-76, 6-81,7-92, 8-191, 9-199, 10-209.Bowling: V. Philander 14.3-8-33-3, D. Steyn 17.3-6-51-2, M. Morkel 19-6-57-2, K. Rabada 16.4-4-34-3,.K. Maharaj 6-0-20-0. SOUTH AFRICA 2nd inningsMarkram c Kumar b Pandya 34D.Elgar c Saha b Pandya 25Rabada not out 2Amla not out 4Extras 0Total 2 wickets (20 overs) 65Fall of wickets:, 1-52, 2-59.Bowling B. Kumar 6-3-16-0, J. Bumrah 4-0-14-0,M .Shami 5-1-15-0, H. Pandya 4-0-17-2, Ashwin 1-0-3-0.
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He was smart not to, because the pitcher threw nothing but balls. But umpire Jerry Meals didn’t see it that way. The end result was Kepler being called out on strikes. But if you look at MLB.com’s strike zone, all five pitches were outside. (MLB.com) https://images.daznservices.com/di/library/sporting_news/e0/3/twins-vs-brewers_1fnagxfqmuznz1km8gv1zal3ww.png?t=-493392285&w=500&quality=80His poor effort was noticed by fans as well.I’m fine if you don’t want to have robot strike zones, but then the trash effort like Jerry Meals has put forth tonight deserve publicly noted fines or discipline from @MLB— Ted (@tlschwerz) August 12, 2020I’m sorry, I have to break my silence. Jerry Meals is having the worst game by an umpire I’ve seen in years. Good lord. #MNTwins— Greg Jensen (@JensenGregory) August 12, 2020This is why there’s a demand for robot umpires. (MLB.com) Twins outfielder Max Kepler had an interesting at-bat Tuesday night.Kepler was facing Brewers pitcher Eric Yardley in the top of the sixth inning. It was a crucial at-bat because the Twins were down by two runs, and had runners on first and second with no outs. While standing at the plate, Kepler didn’t swing at any of Yardley’s pitches. Max Kepler’s strike out https://images.daznservices.com/di/library/sporting_news/54/c5/max-kepler_164z8di1w6g7518cotzys5v2uw.jpg?t=-494175773&w=500&quality=80MORE: What should MLB do with the Cardinals?That obviously looks bad.But maybe it just looks worse because it’s a clear-cut strike zone. Umpires don’t have a magical box in front of them when calling pitches that come hurling toward them at 90-plus mph. So maybe those calls looked a little better when you view the replay.Umpire Jerry Meals took the bat out of Max Kepler’s hands.Three blown strike calls in one at bat. #Twins v #Brewers pic.twitter.com/ijjvSX6Uef— Umpire Auditor (@UmpireAuditor) August 12, 2020Not really.Those are pretty bad calls no matter which way you look at it. The second strike call was especially egregious. The third strike call was at least close enough to where you can’t get too upset, but you can even see Kepler in the video looking at the umpire and point down, indicating it was a low pitch.But that single at-bat wasn’t the only complaint fans had about Meals during Tuesday’s game. A comparison of his called strikes vs. the Twins and vs. the Brewers shows two different strike zones (credit to Baseball Savant).